Piperine has been shown to have a wide range of effects on the body. Thus, the benefits of piperine include:
- reducing inflammation. First, it reduces the levels of cytokines that promote inflammation (IL-1b, TNF-α and PGE2). Consequently, it increases the levels of cytokines that reduce inflammation (IL-10).
- increasing the bioavailability of many drugs and supplements. By inhibiting the detoxification enzymes that break down drugs (such as CYP3A4) and, in addition, increasing the absorption capacity of drugs/substances in the intestine, piperine helps the body to use many other compounds effectively.
- acts as an antioxidant, as piperine absorbs hydroxyl and superoxide radicals. These elements can in some cases lead to serious health problems: inflammation, premature aging, heart disease and some types of cancer. However, Piperine helps fight free radicals, which is why it has a significant positive effect on the body.
- Inhibition of prostaglandins (hormone-like fats), which is very helpful in diarrhea.
- Increased dopamine and serotonin in the brain is a unique benefit of piperine, which helps improve mood, cognitive function and, moreover, fight neurodegenerative diseases.
- Increased muscle metabolism by increasing ATPase activity. This increases energy use by muscles and also helps in weight loss.